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methods@manchester: research methods in the social sciences

Courses related to methods@manchester

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June 2013

  • 10:
    • Designing Early Phase Clinical Trials
      The importance of exploratory clinical research prior to the launch of a large-scale definitive “phase III” clinical trial is becoming increasingly recognised, both in the pharmaceutical industry and in public sector medical research. Early phase trials include first-in-human studies intended to determine a safe dose or range of doses, studies to identify the most effective dose and trials on which a decision whether or not to launch a phase III study will depend. Advances in the identification of medical biomarkers of therapeutic effect and in statistical techniques based on adaptive designs and Bayesian inference now allow such studies to be designed efficiently, to take account of information from a variety of sources and to combine objectives such as establishing safety and seeking evidence of potential benefit. This course presents state of the art methodology for dose-escalation studies and tailor made designs for phase II investigations. The course will be delivered through a mix of lectures, practical sessions and discussion sessions. Topics covered Model-based dose-escalation in Oncology Dose-escalation in Healthy-Volunteer studies Bayesian curve-free dose-escalation for drug combinations Multi-arm multi-stage designs Designs with multiple endpoints Sub-population selection
      Venue: Postgraduate Statistics Centre. Starts at 09:00.
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  • 17:
    • Manchester Methods Summer School
      The inaugural Manchester Methods Summer School will be held at the University of Manchester from June 17 -21, 2013. The school will offer a range of intensive courses, taught by experts in each field. The courses on offer this year focus on social network analysis (two courses), SEM and GLVM modelling, Romani studies, and Ketso.
      Venue: Humanities Bridgeford Street. Starts at 12:00.
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